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The impaired adipogenesis is associated with stress of the endoplasmic reticulum (ER) and elevated expression of unfolded protein response (UPR), both can exacerbate the proinflammatory phenotype of preadipocytes and adipocytes [58]

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Methionine plays a role in breaking down fats, helping to prevent the buildup of fatty deposits in blood vessels that might cause coronary artery disease and blockages in the neck and legs

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