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Moreover, we also searched preprint platform to avoid publication bias

Ismail AM, Hamed AH, Saso S, Thabet HH

Of all the B vitamins, folate has some of the strongest evidence for its use in treating depression : Some research studies have found that high-dose methylfolate may be as effective as some antidepressant medications

There are said to be two allusions to this condition recorded during the 19 th century in The Lancet , which it has not proved possible to trace, but the first clear clinical case report is attributed to Humbert et al