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Viruses 2021;13:210

doi: 10.3390/v8030060 395 XuMZhangWLZhuQZhangSYaoYYXiangTet al

Venigalla, R

Ischemiareperfusion injury exhibits a biphasic ROS burst: xanthine oxidase activation during hypoxia synergizes with mitochondrial electron leakage during reperfusion, causing calcium overload and contractile dysfunction [325]