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Pharmacokinetic studies in humans reveal: Peak plasma concentrations achieved within 5-20 minutes following subcutaneous injection Absolute bioavailability of approximately 6% with subcutaneous administration Volume of distribution ranging between 23.7-25.8 liters in adult subjects Rapid systemic distribution to target pituitary receptors The peptides small molecular size and water solubility facilitate efficient absorption from subcutaneous tissue, though first-pass degradation significantly limits bioavailability compared to intravenous administration

Data extraction Data extraction was conducted in duplicates and independently, using a standardized form to capture animal model details (species, strain, ASD model, sex, age), intervention type (dosage, route, frequency, duration), outcome measures (behavioral assessments, gene expression, neurotransmitters, immune signaling, hormonal measures, gut microbiota composition), and study limitations or any observed adverse effects on the animals

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