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Thus, deletion of AQP4 has been found to reduce infarct volume not only after middle cerebral artery occlusion (which is associated with a massive edema 565 ), but also in experimental models where edema is much less of a confounding factor (distal middle cerebral artery occlusion 569 )

Standard treatment options include surgery, chemotherapy, radiation and targeted therapies

Thirty-two male mice were started on a 60% high-fat diet of 5.24 kcal/g at three weeks of age for 19 weeks, followed by a 45% HFD of 4.73 kcal/g for six additional weeks

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