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Biomed Pharmacother = Biomed Pharmacother

10.3390/cancers11111775 44 HuY

Moreover, the current therapeutic approaches are severely constrained by a lack of understanding of the etiology and the correlations between the environment and behaviors

In such conditions, insufficient peroxisomal fatty acid processing could increase mitochondrial substrate pressure, whereas persistent mitochondrial dysfunction would in turn impair completion of oxidative disposal, establishing a self-reinforcing loop of NEFA accumulation, ROS production, and necroinflammation (60, 61)