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Probiotics, Prebiotics and Synbiotics in Inflammatory Bowel Diseases

A previous study using the BigBlue lacZ reporter system, showed that Polk-/- mice exhibit a spontaneous mutator phenotype 31 , but these findings were limited to the small reporter assay and do not fully reflect the complexity of the genome-wide mutational processes occurring in tissues

In some embodiments, the compositions comprise from about 0.01 milligrams (mg) to about 10 mg of cannabinoid and about 0.5 mg to about 50 mg cofactor or precursor thereof per milliliter of composition