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Methods: This study enrolled a total of 95 CHB patients, 48 achieved HBsAg loss under Peginterferon-alpha (Peg-IFN) therapy while 47 did not

The effects of NMD on the hypoxia response are neither caused by a general downregulation of HIF-1 activity, nor through HIF-1-dependent regulation of NMD, but instead NMD likely acts in parallel to HIF-1 to co-regulate specific aspects of the hypoxia response

It is a ubiquitous, evolutionarily conserved intracellular defense mechanism, a master regulator of cytoprotective enzymes that regulates redox metabolism, inflammation, bone remodeling, and detoxification in multiple auto-immune diseases like inflammatory bowel disease and asthma 62

GSH-assisted lipotransfer is a promising therapeutic strategy for future clinical application