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Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, et al

(*References available below) Protects your skin from damage that causes dullness & aging 450mg daily improved antioxidant levels and reduced oxidative stress in a controlled trial with no reported side effects in clinical studies

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The mechanisms behind the hypotensive and anti-HTN effects of roselle extracts include the stimulation of new blood vessel formation, reduction of myocardial mass, lowering blood viscosity through COX-inhibitory activity, and inhibition of adipocyte differentiation by modulating the phosphatidylinositol 3-kinase/protein kinase B (PI3-K/Akt) and extracellular signal-regulated kinase (ERK) pathways (300)