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Introduction Asthma, a chronic inflammatory disease of the lung, affects up to 300 million people worldwide and remains a major cause of morbidity and mortality ( Despite advances in understanding the cellular drivers of asthma, several fundamental features of the disease remain poorly explained

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This mechanism constructs a pathological intracellular positive feedback loop, forcing macrophages to maintain a high-glycolysis, high-inflammation metabolic state (Warburg effect), which in turn leads to the massive release of inflammatory factors and exacerbates lung tissue injury

The anti-inflammatory regimen can be a potential choice for depression amelioration and prevention in older adults