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Riboflavin seems to function as a proteasome inhibitor 43,45 , resulting in the decreased degradation of the NF-B inhibitor, phosphorylated-inhibitor kappa (P-IB), thus preventing nuclear translocation of NF-B and subsequent pro-inflammatory gene activation 46

Summers, A

Indeed, intestinal epithelial organoids from Gpx4 +/IEC mice, but not WT controls, displayed signs of LPO and increased Cxcl1 expression on AA and ferric iron exposure (Fig