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The link between ammonia-induced cell death and necrosis is likely due to the local accumulation of ammonia at high concentrations, which disrupts cell membrane integrity and initiates necrotic responses such as cell swelling, membrane rupture, and the leakage of intracellular components into the extracellular space (117, 118)

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Teixeira et al., 2018)], and C-X-C motif chemokine 10 (CXCL10, which was shown to mediate leukocyte influx across the BBB in a variety of inflammatory CNS diseases) (Michlmayr and McKimmie, 2014)