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In psoriasis, SCFAs exert their effects through: (i) activation of GPCRs and inhibition of HDACs, (ii) regulation of both innate (neutrophils, macrophages, dendritic cells) and adaptive (T and B lymphocytes) immune responses, particularly correcting Th17/Treg imbalance, and (iii) maintenance of gut barrier integrity [138]

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Contrary to the anti-inflammatory role in murine DC, activation of AMPK was recently shown to support OXPHOS reprogramming and interferon type I & III production in TLR7/9 activated human pDC 58