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Shikami M, Konopleva M, Samudio I, Hoshino K, Garcia-Manero G, Kojima K, Tsao T, McQueen T, Andreeff M

Almazov National Medical Research Center Email: [email protected] ORCID iD: 0000-0001-7347-6104 SPIN-code: 5329-5420 MD, PhD Russian Federation, Saint Petersburg

To evaluate the structural impact of G1228D mutation, we visualized the G1228 in the three Cryo-EM structures of bovine MRP1 40,44 , the apo, LTC 4 -bound and ATP-bound structures (Fig