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Dong et al

Product Purchase Includes Medication Medical provider consultation Syringes Alcohol Pads Program guide Administration video Administration and Frequency Available in Subcutaneous (SQ) and Intramuscular (IM) Injections Three times weekly As directed by your prescribing provider Contraindications Compounded Methylcobalamin injections should not be used in individuals who: Have a known hypersensitivity or allergy to cyanocobalamin, methylcobalamin, cobalt, or any component of the formulation Have Leber's disease (hereditary optic nerve atrophy) B12 administration may cause rapid optic atrophy in these patients Have polycythemia vera B12 may accelerate red blood cell production in ways that may be harmful in this condition Use during pregnancy or breastfeeding should occur only if a licensed healthcare provider determines that potential benefits outweigh potential risks

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Furthermore, there were no differences between treatment groups for Simpsons Diversity Index (Supplementary Fig