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It has been previously reported that homo-GATA4 and hetero-GATA4 knockout murine embryos suffer early developmental arrest owing to functional deficiencies in the extraembryonic visceral endoderm [34, 35]

The sustained elevation of synaptic 5-HT eventually causes desensitization of 5-HT 1A auto-receptors, which normally shut down endogenous 5-HT release in the presence of excess 5-HT - this desensitization may be necessary for the full clinical effect of SSRIs and may be responsible for their typically prolonged onset of action

Han XG, Wang DK, Gao F, Liu RH, Bi ZG

To view a copy of this licence, visit About this article Cite this article Abdalla, M.A., Waqas, K., Neugart, S