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These refined parameters demonstrate that cyclodextrin complexation not only accelerates initial systemic entry but also optimizes the local availability of thymol within the gut

Structured evidence overview Conclusions Strongest clinical signal: prevention of oxaliplatin-induced peripheral neuropathy, where IV GSH 1,500 mg/m2 before oxaliplatin reduces clinically significant neurotoxicity without compromising antitumor efficacy

The current standard-of-care GBM therapeutic protocol, regardless the status of the molecular indicators of disease severity, includes the maximal safe surgical resection while preserving neurological function, followed by radiotherapy plus concomitant and adjuvant chemotherapy with temozolomide (TMZ) [2, 3]

10.4269/ajtmh.20-0473 Am J Trop Med Hyg