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Greig D, Alcaino H, Castro PF, Garcia L, Verdejo HE, Navarro M, et al

2 Erythrocytes are particularly vulnerable to oxidative stressors due to their role in oxygen transport, thus acute hemolytic anemia is the main associated pathology

Inside the cell, the -glutamyl amino acid is hydrolyzed by -glutamyl cyclo-transferase and converted into oxoproline and a free amino acid

Glutathione might inhibit the effects of cerebral infarction and enhance antiapoptotic signaling after ischemic stroke, suggesting that GSH may be a potent therapeutic antioxidant that can attenuate severe pathologies after ischemic stroke, and stimulating GSH synthesis through administration of GSH precursors and micronutrients like selenium can optimize GSH and GSH peroxidase for optimal antioxidant defense in cerebral ischemia (155, 156)