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Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways

Mechanism of Action: Octopamine replaces norepinephrine in sympathetic neurons with chronic use of monoamine oxidase inhibitors Dopamine beta-hydroxylase converts tyramine to octopamine Octopamine can be taken up into storage vesicles in nerve terminals, and then be released by nerve stimulation Octopamine exerts only a small effect on postsynaptic receptors compared to norepinephrine (hence the designation false transmitter) Notes: Octopamine typically exists in only trace amounts in the mammalian CNS, but accumulates when MAO is inhibited (e.g

To improve the pharmacological properties and enable tumor-selectivity, the phenylazopyridine ligand was terminally functionalized with a hydroxy group that could be used for further chemical modifications

D., Ishak K