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The methaemoglobinaemia induced in these mice by sodium nitrite peaked later and at a lower level than the methaemoglobinaemia induced by hydroxylamine or 4-dimethylaminophenol, but was longer lasting (Kruszyna et al., 1982)

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Most of the risks of these compounds stem from the absence of clinical trials and reliable data in humans, making it impossible to establish appropriate dosing, long-term safety, or adverse event profiles