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Disrupted circadian rhythms, in night shift workers for example, increase intestinal permeability

GSNO concentration can be regulated by GSNO-reductase (GSNOR), which provides the brake for signal transduction

With the emergence and expanding understanding of the microbiotagutkidney axis, increasing evidence indicates that intestinal barrier disruption, abnormal microbial metabolite production, and intestinal mucosal immune dysregulation play critical roles in the pathogenesis of various kidney diseases

RNA was analyzed using the TaqMan probe hsa-miR122 (Cat: 002245, ThermoFisher), with normalization performed against the ath-miR159a probe (Cat: 000338, ThermoFisher)