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Mtodos Se combinaron y analizaron datos provenientes de 7 ensayos multicntricos, doble ciego y controlados con placebo de 6 a 12 meses en pacientes con sobrepeso u obesidad (ndice de masa corporal (IMC) de 28-43 kg/m2), con diabetes tipo 2 (hemoglobina glicosilada (HbA1c) de 6,5 a menos de 13%)

This study observed protein aggregation during refolding upon inclusion body freezethaw in 2 M urea + 1 mM DTT in 50 mM Tris buffer, which resulted in poor overall recovery and low bioactivity [33]

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DSIP has promising research applications for treating sleep disorders, managing anxiety and stress-related conditions, and offering neuroprotection