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Under hypoxic conditions, hypoxia-inducible factor-1 alpha (HIF-1) fails to undergo ubiquitination and degradation, then undergoes nuclear translocation to bind to promoters on the vascular endothelial growth factor gene, finally increasing the expression of HIF-1 and VEGF in endometriotic lesions

Therefore, characterization of the specific salivary biomarkers associated with presence of CD and its severity could have a major impact on the diagnosis and monitoring of this disease (49)

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