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N-glucuronides of 4-aminobiphenyl and N-hydroxy-4-aminobiphenyl can be hydrolyzed by acidic urine to their corresponding arylamines, they can in turn enter the bladder epithelium and undergo further metabolism by peroxidation and/or O-acetylation to form DNA adducts

The autophagy machinery relies on the ATG (autophagy related) protein family, which forms distinct protein complexes to control the generation of the membrane compartments that are the morphological and functional hallmark of this process [142]

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