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2.1.2 Iron transport in brain Iron is an essential cofactor for many metabolic processes in the central nervous system (CNS), including DNA synthesis in neurons, oxidative phosphorylation, neurotransmitter production and oxygen transport ( Figure 2 )

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Emerging evidence suggests that irisin may influence protein clearance pathways such as autophagy and the ubiquitin-proteasome system (UPS)

doi: 10.3389/fmicb.2025.1589946 Received 08 March 2025 Accepted 29 May 2025 Published 01 July 2025 Volume 16 - 2025 Edited by Jun Zhou, Shandong First Medical University, China Reviewed by Yun Peng Fan, Northwest A&F University, China Chuanmin Ma, Jinan Center for Disease Control and Prevention, China Ziming Wang, Hospital of Chengdu University of Traditional Chinese Medicine, China Yong Wang, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, China Updates Copyright 2025 Li, Chen, Xu, Li and Li