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In cancer patients, iron loss could also be due to diarrhea, both as a cancer symptom and as a consequence of anti-neoplastic drugs (354)

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Additionally, the aggregation-enhancing A315T and Q343R mutations have been shown to increase TDP-43-containing RNA granule's average sizes, decrease their distribution density and also hamper their mobility in the neuronal cells (Liu-Yesucevitz et al., 2014)

4582-C THE PRESENCE OF FATTY LIVER IS ASSOCIATED WITH HIGHER TREATMENT RESPONSE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS Leandro Sierra 1 , Romelia Barba Bernal 1 , Ana Marenco-Flores 1 , Bryan Ferrigno 2 , Daniela Goyes 3 , Wilfor Diaz Fernandez 2 , John Esli Medina Morales 4 , Alan Bonder 1 , Vilas Patwardhan 1 and ALD team, (1)Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, (2)Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, (3)Yale University Medical Center, New Haven, CT, United States, (4)Rutgers New Jersey Medical School, Kearny, NJ Background: Primary biliary cholangitis (PBC) is an autoimmune, chronic cholestatic liver disease involving bile ducts