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157 FMRP is an RNA-binding protein whose target mRNAs encode transcription factors, and chromatin modifiers have been identified by high-throughput sequencing of RNA isolated with cross-linking immunoprecipitation (HITS-CLIP)

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While identification of the different molecular signatures and genotypes among responders and non-responders may help develop predictive biomarkers to enable patient stratification in clinical setting, the molecular and genetic heterogeneity in many tumors is still a big challenge for successful cancer therapy [182]

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