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On macroscopic histological examination, the sectioned sciatic nerve after surgical repair showed retrograde regeneration and reinnervation to adjacent muscle bundles ( Figure 4 )

Luedde M, et al

A.MutaniA.RamsubhagA.BruntJ.AustinB

Inhibiting mTOR signaling in CAR T cells alters immunometabolism and enhances function Intrigued by our pre- and post-infusion results suggesting a significant role for mTOR activity on the efficacy of CAR T cells of LTR, we asked whether we could harness the mTOR pathway to enhance antitumor activity of CAR T cells of STR