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With high protein turnover or an unbalanced diet, supplementation can be a useful addition to daily nutrition, just like vitamins

Here are the most common factors: Vitamin Deficiency White Patches on Face A lack of essential vitamins and minerals especially Vitamin B12, Vitamin D, and calcium can sometimes lead to loss of pigmentation, resulting in white spots

Statistical analysis Statistical analysis was done using one tailed students t-test for pair wise comparison or ANOVA followed by post-hoc Tukey test for multiple sample comparisons

The keywords used were nano and responsive, combined with the International Patent Classification (IPC) to focus on the biomedical field, specifically IPC classification numbers A61P, A61K, C07K, C07H, C12N, C12Q, and G01N (e.g., A61K stands for specific preparations for medical, dental, or toiletry purposes)