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Species interaction at the cellular level, dispersion or intercellular lipids extraction, increased fluidity of stratum corneum lipid bilayers, higher drug thermodynamic activity, and greater SC hydration are all mechanisms that support drug administration using chemical enhancers [283]

Compounding these issues, the adverse side-effects of current drugs are associated with frequent medication changes and high rates of non-adherence to treatment [10]

Potential signs and symptoms include: Skin Raised, reddish patches covered with thick, silvery-white, shiny scales, which may be itchy Pinpoint bleeding spots appear when scales are scraped off (Auspitz sign) Systemic Fever, dehydration, and elevated white blood cell count may occur in severe cases Other Joint stiffness or pain, including inflammation or damage in psoriatic arthritis Diagnosis The diagnosis of psoriasis is based on a physical examination of the skin, scalp, and nails

10.1016/j.jep.2024.117874 137 ZhaoF.HuangY.JiJ.LiuX.LiX.ZouL.et al (2024)