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NieZLiuYZhangMWuCCaoQXuJet al

doi: 10.3390/nu5083184

This article synthesizes peer-reviewed research on GHK-Cus biological activity and its rapidly expanding applications in clinical aesthetics

By suppressing TGF-1 expression and preventing Smad2/3 phosphorylation, luteolin downregulates core ECM components, such as collagen I, fibronectin, and alpha-smooth muscle actin (-SMA), thereby limiting myofibroblast activation and pathological ECM accumulation